Millimeter/centimeter-scale origami robots have recently been explored for biomedical applications due to their inherent shape-morphing capability. However, they mainly rely on passive or/and irreversible deformation that significantly hinders the clinic functions in an on- demand manner. Here, we report magnetically actuated origami robots that can crawl and swim for effective locomotion and targeted drug delivery in severely confined spaces and aqueous environments. We design our robots based on the Kresling origami, whose thin shell structure 1) provides an internal cavity for drug storage, 2) permits torsion-induced contraction as a crawling mechanism and a pumping mechanism for controllable liquid medicine dispensing, 3) serves as propellers that spin for propulsion to swim, 4) offers anisotropic stiffness to overcome the large resistance from the severely confined spaces in biomedical environments. These magnetic origami robots can potentially serve as minimally invasive devices for biomedical diagnoses and treatments. Renee Zhao Assistant Professor Mechanical Engineering Stanford University To ask the speaker a question, click on the speech bubble icon in the lower right hand corner and type in the question in the window that pops up. The question will be sent directly to us. Please note that there is a little bit of a delay when streaming. What participants see is a few minutes behind what is happening at our end. The longer we stream, the greater the delay may become so the questions submitted at the very end may not reach us in time. The best way to get the questions answered is to send them as they come up.